Structures of thrombospondins [Review]: Thrombospondins: from structure to therapeutics

C. Britt Carlson; Jack Lawler; Deane F. Mosher

doi:10.1007/s00018-007-7484-1

Structures of thrombospondins [Review]: Thrombospondins: from structure to therapeutics

C. Britt Carlson
, Jack Lawler
, Deane F. Mosher

Parkland College

University of Wisconsin - Madison

Research output: Contribution to journal › Article › peer-review

Abstract

Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review)

Original language	American English
Article number	672
Pages (from-to)	672-686
Journal	Cellular and Molecular Life Sciences
Volume	65
DOIs	https://doi.org/10.1007/s00018-007-7484-1
State	Published - Mar 2008

Keywords

Thrombospondin
extracellular protein structure
cartilage oligomeric matrix protein
calcium

Disciplines

Biochemistry, Biophysics, and Structural Biology
Structural Biology

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10.1007/s00018-007-7484-1License: Unspecified

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title = "Structures of thrombospondins [Review]: Thrombospondins: from structure to therapeutics",

abstract = " Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review) ",

keywords = "Thrombospondin, extracellular protein structure, cartilage oligomeric matrix protein, calcium",

author = "Carlson, \{C. Britt\} and Jack Lawler and Mosher, \{Deane F.\}",

note = "Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins",

year = "2008",

month = mar,

doi = "10.1007/s00018-007-7484-1",

language = "American English",

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pages = "672--686",

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AU - Carlson, C. Britt

AU - Lawler, Jack

AU - Mosher, Deane F.

N1 - Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins

PY - 2008/3

Y1 - 2008/3

N2 - Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review)

AB - Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review)

KW - Thrombospondin

KW - extracellular protein structure

KW - cartilage oligomeric matrix protein

KW - calcium

UR - https://link.springer.com/article/10.1007/s00018-007-7484-1

U2 - 10.1007/s00018-007-7484-1

DO - 10.1007/s00018-007-7484-1

M3 - Article

SN - 1420-9071

VL - 65

SP - 672

EP - 686

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

M1 - 672

ER -

Structures of thrombospondins [Review]: Thrombospondins: from structure to therapeutics

Abstract

Keywords

Disciplines

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